ironjustice
2009-01-29 01:33:03 UTC
In this study they find a low zinc intake linked to diabetes.
They also find the HIGHER the zinc the LOWER the iron and the LESS
diabetes there is.
Iron competes with zinc in the body.
"Inverse association for dietary zinc to heme iron ratio"
Sooo .. it kind of makes sense the use of iron chelating picolinic
acid WITH zinc .. zinc picolinate .. would be an effective insulin
mimetic / treatment for diabetes.
The zinc displaces the iron and the chelator removes the iron.
I got a bridge for sale ..
A Prospective Study of Zinc Intake and Risk of Type 2 Diabetes in
Women.Diabetes Care. 2009 Jan 26.
Sun Q, van Dam RM, Willett WC, Hu FB.
From the Departments of Nutrition (QS, RWCW, and FBH) and of
Epidemiology (WCW and FBH), Harvard School of Public Health, Boston,
MA; the Channing Laboratory (RMD, WCW, and FBH), Department of
Medicine, Brigham and Women's Hospital and Harvard Medical School,
Boston, MA.
Objective-
The aim of this study is to investigate the intake of zinc in relation
to risk of type 2 diabetes in U.S. women.
Research design and methods-
Dietary intakes of zinc and other nutrients were assessed and updated
using of a validated food frequency questionnaire from 1980 to 2002
among 82,297 women who were aged 33-60 years at baseline in 1980 and
followed up to 2004 in the Nurses' Health Study.
Results-
During the 24 years of follow-up, 6,030 incident cases of type 2
diabetes were ascertained. After adjustment of lifestyle and dietary
risk factors, the relative risks of type 2 diabetes (95% CI) comparing
the highest with the lowest quintiles were 0.90 (0.82, 0.99, P(trend)
= 0.04) for total zinc intake and 0.92 (0.84, 1.00, P(trend) = 0.009)
for dietary zinc intake from food sources, respectively. We further
found an inverse association for dietary zinc to heme iron ratio.
After multivariate adjustment of covariates, the relative risks (95%
CI) across quintiles of this ratio were 1.0 (reference), 0.93 (0.86,
1.01), 0.86 (0.79, 0.94), 0.82 (0.75, 0.90), and 0.72 (0.66, 0.80; P
(trend) < 0.0001), respectively.
Conclusions-
Higher zinc intake may be associated with a slightly lower risk of
type 2 diabetes in women. More studies are warranted to confirm this
association and to explore potential mechanisms.
PMID: 19171718
----------------------
Here they mix zinc with maltol ANOTHER iron chelator .. and then they
also .. mix zinc with allixin ANOTHER iron chelator found in garlic.
"Potent candidate for the treatment of type 2 diabetes"
The pharmacology of the insulinomimetic effect of zinc complexes.
Biometals. 2005 Aug;18(4):319-23.
Sakurai H, Adachi Y.
Department of Analytical and Bioinorganic Chemistry, Kyoto
Pharmaceutical University, 5 Nakauchi-oho, Misasagi, Japan.
***@mb.kyoto phu.acjp
In developing new insulinomimetic zinc(II) complexes with different
coordination structures and with a blood glucose-lowering effect to
treat type 2 diabetic animals, we found a potent bis(maltolato)zinc
(ll) complex, Zn(mal)(2).
Using the complex as the leading compound, we examined the in vitro
and in vivo structure-activity relationships of Zn(mal)(2) and its
related complexes in respect to the inhibition of free fatty acids
(FFA) release and the enhancement of glucose uptake in isolated rat
adipocytes treated with epinephrine (adrenaline), and hypoglycemic
activity.
Among the compounds tested, a new Zn(II) complex with allixin that was
isolated from garlic, bis(allixinato)Zn(II), Zn(alx)(2), was found to
exhibit the highest insulin-mimetic and hypoglycemic activities in
type 2 KK-A(y) diabetic mice.
On the basis of the results, Zn(alx)(2), complex was proposed to be
a .
PMID: 16158223
-------------------
Normalizing Effect of Zinc(II) Complex with 6-Ethoxy Picolinic Acid on
Blood Glucose Levels in KK-A'y' Mice
MORISHITA MIKA ,NISHIDE MIDORI , MATSUMOTO KINUYO, ADACHI
YUSUKE ,YOSHIKAWA YUTAKA ,SAKURAI HIROMU, KAJIWARA NAEMI
Biomed Res Trace Elem
Abstract;
We examined normalizing effect for blood glucose levels of zinc(II)
complex with 6-ethoxy picolinic acid (Zn(6-EtOpa)2) on KK-A'y' mice
which used in this study as the model animals of type 2 diabetes, and
compared with its ligand, 6-ethoxy picolinic acid (6-EtOpa).
These mice were divided into three groups after the onset of diabetes
at 8 weeks of age, which were an untreated group, a 6-EtOpa treated
group, and a Zn(6-EtOpa)2 treated group.
They were given daily intraperitoneal (i.p.) injections of each
material for a period of 2 weeks from 8th to 10th week of ages.
The dose of Zn(6-EtOpa)2 was 3 mg Zn/kg of body weight.
Each animal was examined for its body weight, food intake, blood
glucose level, glucose tolerance, HbA1c level, hematological status,
organ weight, and zinc and copper concentrations in the organs.
After 2 weeks of administration, the blood glucose level of KK-A'y'
mice treated with Zn(6-EtOpa)2 showed a significant decrease compared
to both of the 6-EtOpa and control groups.
Furthermore, the mice treated with Zn(6-EtOpa)2 showed decreasing
effect on HbA1c levels and increasing effect on glucose tolerance.
Zinc (II) concentration in the femur was significantly increased in
the Zn(6-EtOpa)2 treated group compared to the both of 6-EtOpa and
control groups.
Copper concentration was decreased significantly in both of femur and
femoris muscle.
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/634q5a
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
They also find the HIGHER the zinc the LOWER the iron and the LESS
diabetes there is.
Iron competes with zinc in the body.
"Inverse association for dietary zinc to heme iron ratio"
Sooo .. it kind of makes sense the use of iron chelating picolinic
acid WITH zinc .. zinc picolinate .. would be an effective insulin
mimetic / treatment for diabetes.
The zinc displaces the iron and the chelator removes the iron.
I got a bridge for sale ..
A Prospective Study of Zinc Intake and Risk of Type 2 Diabetes in
Women.Diabetes Care. 2009 Jan 26.
Sun Q, van Dam RM, Willett WC, Hu FB.
From the Departments of Nutrition (QS, RWCW, and FBH) and of
Epidemiology (WCW and FBH), Harvard School of Public Health, Boston,
MA; the Channing Laboratory (RMD, WCW, and FBH), Department of
Medicine, Brigham and Women's Hospital and Harvard Medical School,
Boston, MA.
Objective-
The aim of this study is to investigate the intake of zinc in relation
to risk of type 2 diabetes in U.S. women.
Research design and methods-
Dietary intakes of zinc and other nutrients were assessed and updated
using of a validated food frequency questionnaire from 1980 to 2002
among 82,297 women who were aged 33-60 years at baseline in 1980 and
followed up to 2004 in the Nurses' Health Study.
Results-
During the 24 years of follow-up, 6,030 incident cases of type 2
diabetes were ascertained. After adjustment of lifestyle and dietary
risk factors, the relative risks of type 2 diabetes (95% CI) comparing
the highest with the lowest quintiles were 0.90 (0.82, 0.99, P(trend)
= 0.04) for total zinc intake and 0.92 (0.84, 1.00, P(trend) = 0.009)
for dietary zinc intake from food sources, respectively. We further
found an inverse association for dietary zinc to heme iron ratio.
After multivariate adjustment of covariates, the relative risks (95%
CI) across quintiles of this ratio were 1.0 (reference), 0.93 (0.86,
1.01), 0.86 (0.79, 0.94), 0.82 (0.75, 0.90), and 0.72 (0.66, 0.80; P
(trend) < 0.0001), respectively.
Conclusions-
Higher zinc intake may be associated with a slightly lower risk of
type 2 diabetes in women. More studies are warranted to confirm this
association and to explore potential mechanisms.
PMID: 19171718
----------------------
Here they mix zinc with maltol ANOTHER iron chelator .. and then they
also .. mix zinc with allixin ANOTHER iron chelator found in garlic.
"Potent candidate for the treatment of type 2 diabetes"
The pharmacology of the insulinomimetic effect of zinc complexes.
Biometals. 2005 Aug;18(4):319-23.
Sakurai H, Adachi Y.
Department of Analytical and Bioinorganic Chemistry, Kyoto
Pharmaceutical University, 5 Nakauchi-oho, Misasagi, Japan.
***@mb.kyoto phu.acjp
In developing new insulinomimetic zinc(II) complexes with different
coordination structures and with a blood glucose-lowering effect to
treat type 2 diabetic animals, we found a potent bis(maltolato)zinc
(ll) complex, Zn(mal)(2).
Using the complex as the leading compound, we examined the in vitro
and in vivo structure-activity relationships of Zn(mal)(2) and its
related complexes in respect to the inhibition of free fatty acids
(FFA) release and the enhancement of glucose uptake in isolated rat
adipocytes treated with epinephrine (adrenaline), and hypoglycemic
activity.
Among the compounds tested, a new Zn(II) complex with allixin that was
isolated from garlic, bis(allixinato)Zn(II), Zn(alx)(2), was found to
exhibit the highest insulin-mimetic and hypoglycemic activities in
type 2 KK-A(y) diabetic mice.
On the basis of the results, Zn(alx)(2), complex was proposed to be
a .
PMID: 16158223
-------------------
Normalizing Effect of Zinc(II) Complex with 6-Ethoxy Picolinic Acid on
Blood Glucose Levels in KK-A'y' Mice
MORISHITA MIKA ,NISHIDE MIDORI , MATSUMOTO KINUYO, ADACHI
YUSUKE ,YOSHIKAWA YUTAKA ,SAKURAI HIROMU, KAJIWARA NAEMI
Biomed Res Trace Elem
Abstract;
We examined normalizing effect for blood glucose levels of zinc(II)
complex with 6-ethoxy picolinic acid (Zn(6-EtOpa)2) on KK-A'y' mice
which used in this study as the model animals of type 2 diabetes, and
compared with its ligand, 6-ethoxy picolinic acid (6-EtOpa).
These mice were divided into three groups after the onset of diabetes
at 8 weeks of age, which were an untreated group, a 6-EtOpa treated
group, and a Zn(6-EtOpa)2 treated group.
They were given daily intraperitoneal (i.p.) injections of each
material for a period of 2 weeks from 8th to 10th week of ages.
The dose of Zn(6-EtOpa)2 was 3 mg Zn/kg of body weight.
Each animal was examined for its body weight, food intake, blood
glucose level, glucose tolerance, HbA1c level, hematological status,
organ weight, and zinc and copper concentrations in the organs.
After 2 weeks of administration, the blood glucose level of KK-A'y'
mice treated with Zn(6-EtOpa)2 showed a significant decrease compared
to both of the 6-EtOpa and control groups.
Furthermore, the mice treated with Zn(6-EtOpa)2 showed decreasing
effect on HbA1c levels and increasing effect on glucose tolerance.
Zinc (II) concentration in the femur was significantly increased in
the Zn(6-EtOpa)2 treated group compared to the both of 6-EtOpa and
control groups.
Copper concentration was decreased significantly in both of femur and
femoris muscle.
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/634q5a
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk