Gumbo
2009-09-04 19:25:45 UTC
Revealing The Anti-Diabetic Effects Of Sodium Tungstate
Main Category: Diabetes
Also Included In: Genetics; Biology / Biochemistry
Article Date: 31 Aug 2009 - 0:00 PDT
The molecular mechanisms of tungstate activity in diabetes have been
uncovered. Researchers writing in the open access journal BMC Genomics have
identified the pathways through which sodium tungstate improves pancreatic
function and beta cell proliferation.
A team led by Professor Ramon Gomis at the Hospital Clinic de Barcelona,
Spain, studied the effects of sodium tungstate on pancreatic gene expression
in a rat model of diabetes, in order to discover the mechanisms that control
the partial pancreatic regeneration induced by this treatment. He said, "A
detailed description of the pathways involved in the pancreatic effects of
tungstate is provided in our paper. Essentially, tungstate improves
pancreatic function through a combination of hyperglycemia-independent
pathways and through its own direct and indirect effects. In addition, the
MAPK pathway has a key role in the tungstate-induced increase of beta cell
proliferation".
Speaking about the results, Professor Gomis said, "We used sodium tungstate
treatment of diabetic animals as a tool to search for genes and pathways
implicated in pancreatic regeneration after an injury to the pancreas. This
study identified genes with a key role in improving pancreatic plasticity,
and these could be used as therapeutic targets for the future treatment of
diabetes"
Notes:
Molecular mechanisms of tungstate-induced pancreatic plasticity: a
transcriptomics approach
Jordi Altirriba, Albert Barbera, Hector Del Zotto, Belen Nadal, Sandra
Piquer, Alex Sanchez-Pla, Juan J Gagliardino and Ramon Gomis
BMC Genomics (in press)
http://www.biomedcentral.com/bmcgenomics/
Source:
Graeme Baldwin
BioMed Central
http://www.medicalnewstoday.com/articles/162249.php
Disclaimer: Any medical information published is not intended as a
substitute for informed medical advice and you should not take any action
before consulting with a health care professional. For more information,
please read our terms and conditions.
Main Category: Diabetes
Also Included In: Genetics; Biology / Biochemistry
Article Date: 31 Aug 2009 - 0:00 PDT
The molecular mechanisms of tungstate activity in diabetes have been
uncovered. Researchers writing in the open access journal BMC Genomics have
identified the pathways through which sodium tungstate improves pancreatic
function and beta cell proliferation.
A team led by Professor Ramon Gomis at the Hospital Clinic de Barcelona,
Spain, studied the effects of sodium tungstate on pancreatic gene expression
in a rat model of diabetes, in order to discover the mechanisms that control
the partial pancreatic regeneration induced by this treatment. He said, "A
detailed description of the pathways involved in the pancreatic effects of
tungstate is provided in our paper. Essentially, tungstate improves
pancreatic function through a combination of hyperglycemia-independent
pathways and through its own direct and indirect effects. In addition, the
MAPK pathway has a key role in the tungstate-induced increase of beta cell
proliferation".
Speaking about the results, Professor Gomis said, "We used sodium tungstate
treatment of diabetic animals as a tool to search for genes and pathways
implicated in pancreatic regeneration after an injury to the pancreas. This
study identified genes with a key role in improving pancreatic plasticity,
and these could be used as therapeutic targets for the future treatment of
diabetes"
Notes:
Molecular mechanisms of tungstate-induced pancreatic plasticity: a
transcriptomics approach
Jordi Altirriba, Albert Barbera, Hector Del Zotto, Belen Nadal, Sandra
Piquer, Alex Sanchez-Pla, Juan J Gagliardino and Ramon Gomis
BMC Genomics (in press)
http://www.biomedcentral.com/bmcgenomics/
Source:
Graeme Baldwin
BioMed Central
http://www.medicalnewstoday.com/articles/162249.php
Disclaimer: Any medical information published is not intended as a
substitute for informed medical advice and you should not take any action
before consulting with a health care professional. For more information,
please read our terms and conditions.